Tag: <span>biodefense</span>

Synthetic Antibodies: The Emerging Field of Aptamers

The current global market for aptamers is approximately $99 million annually and is anticipated to increase at an astonishing compound annual growth rate (CAGR) of 106.3% for the next five years resulting in an estimated value of $3.7 billion by the year 2017. Sometimes referred to as a “synthetic antibody,” an aptamer is a nucleic acid or peptide molecule that binds to a target or antigen with high affinity and specificity. Aptamers have a wide range of applications including diagnostics, therapeutics, forensics, and biodefense. To date, hundreds of aptamer sequences have been identified and can now be chemically synthesized in the lab on demand, faster and less expensively, without the traditional issues associated with producing recombinant antibodies. This article will review aptamer technology, its advantages and limitations, as well as highlight a few of its many applications in the life sciences…

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Biologics Production

aptamers biodefense forensics life sciences nucleic acid peptide molecule synthetic antibody therapeutics

Development and Assessment of a Novel Device for the Controlled, Dry Thawing of Cryopreserved Cell Products

While playing an integral role in biotechnology and medicine, cryopreservation (CP) is often viewed as a “simple tool” and is overlooked as a critical and evolving component of cell and tissue bioprocessing. Despite this, cryopreservation serves as an enabling technology in numerous areas including the latest cell therapies. For example, over one third of the cells used in clinical trials are cryopreserved using the traditional methods, which in many cases yield suboptimal outcomes. Further, researchers still rely on the assessment of cell survival immediately post-thaw (within a few hours), and fail to account for the impact of cryopreservation-induced delayed-onset cell death (CIDOCD) which continues to impact survival from hours to days post-thaw.

Read MoreDevelopment and Assessment of a Novel Device for the Controlled, Dry Thawing of Cryopreserved Cell Products

Biologics Biologics Production Bioreactor Scale-Up Cell & Gene Therapy Cell Lines Fed-Batch Bioreactor Process HEK293 Mammalian Cell Culture Manufacturing Regulatory Viral Reference Materials Viral Vectors

biodefense cell recovery cell repopulation cell research cell therapy cell viability cellular preservation cellular products cp cryopreservation cryothawing dmso dry thawing gene therapy high-throughput screening research science smartthaw stem cells water bath thawing