By Willem Kools, PhD
Volume 11, Issue 2 (Summer 2012)
Mammalian cell culture processes used in the production of monoclonal and recombinant proteins require orthogonal steps in the downstream process to clear virus. Virus filtration is a common, size exclusion-based method in these processes. Initially, tangential flow products were used, but as a result of new-generation virus filtration products, most operations are now constant-pressure, normal-flow operations that can be executed in a single shift operation. The virus filtration step toward the end of the downstream process is now yielding increased protein concentrations…
Citation: Kools W. Process Development Toward a Robust and Economically-Sized Virus Filtration Process. BioProcess J, 2012; 11(2): 42-47. https://dx.doi.org/10.12665/J112.Kools
Posted online July 20, 2012