Process characterization using qualified scale-down models (SDM) offers time and resource-saving advantages to companies developing biotherapeutics. Current approaches with glass benchtop bioreactors as SDMs have demonstrated the ability to predict process performance and product quality, but are throughput- limited by infrastructure that requires significant operational input, as well as large volumes of media and reagents. In this article, the Sartorius Stedim Biotech ambrÂź250 high-throughput, single-use mini bioreactor system will be discussed for its suitability as an SDM for process characterization.
Tag: <span>data integrity</span>
Fresh on the heels of Mission #3 at the stiflingly hot Death Valley National Park, the ARTEL Extreme Pipetting Expedition team looked forward to visiting the temperate and humid Olympic National Park. Known for its lush, rainforest-like conditions, Olympic is home to 266 glaciers, more than 60 miles of rugged Pacific coastline, and over 140 inches of rainfall each year. It also has the Northwestâs largest remaining acreage of undisturbed rain forests…
As the ARTEL Extreme Pipetting Expedition team set out for Mission #3, only one thing was certain â it was about to get much hotter. Heading to Death Valley National Park in the desert spanning Nevada and California, the Expeditionâs goal was to test the effect of dry heat on pipetted volumes. As the sun beat down and the temperature rose, the cold temperatures of Mt. Washington (Mission #1) and the mild climate at Yellowstone National Park (Mission #2) seemed like distant memories to the Expedition team…
After braving the home of the worldâs worst weather to study the affect of barometric pressure on pipette volumes, the ARTEL Extreme Pipetting Expedition team embarked on its next mission to explore the impact of another environmental condition on laboratory data. The destination: Yellowstone National Park, boasting the worldâs largest active geyser field, and more than 10,000 geysers, steam vents and mud pots. The ARTEL team landed in the 2.2 million acre park and realized they were certainly not in Mount Washington, New Hampshire anymore (the venue for Mission #1). As hot springs bubbled and a geyser spewed steam up to 135 feet in the air just a short distance from Expedition members, the thermal variation at Yellowstone National PÂÂÂark was evidentâŠ