Tag: <span>biomass assay</span>

Of the available on-line biomass assays, the radio-frequency (RF) impedance method has a clear advantage for current good manufacturing process (cGMP) because it is an unambiguous reflection of viable cell bio-volume rather than the total number of cells. Although other more approximate methods are available for cells in suspension, RF impedance is practically the only on-line method available for cells in suspension, attached to microcarriers and immobilized cells at high cell densities. Data are presented to show how live cell concentrations are derived from an RF impedance-derived instrument…