by Klaus Tarrach
Volume 6, Issue 3 (Fall 2007)
Monoclonal antibodies and recombinant proteins have increased in importance and gained success as therapeutic agents in treating various diseases. Biomanufacturing of such a biopharmaceutical product by cell culture follows a main route. Upstream processing is strictly biology-driven, while on the other hand, purification is engineering driven. Fermentation is setting the pace. To some extent, that pace is a result of recent advances in cell culture, greatly increasing the densities of cells along with cell-related contaminants…
Citation:
Tarrach K. Process Economy of Disposable Chromatography and Nanofiltration In Antibody Manufacturing. BioProcess J, 2007; 6(3): 52-55. http://dx.doi.org/10.12665/J63.Tarrach