by Michel Kobr, Philippe Chatellard, and Markus O. Imhof, PhD
Volume 7, Issue 2 (Summer 2008)
Expression vector and cell line engineering is the basis for expression and industrial production of biopharmaceuticals. The ultimate goal is to obtain clonal cell lines that secrete the protein of interest with high cell-specific productivity, and at consistently high levels over an extended number of cell generations, allowing for scale-up and cost-efficient large-scale manufacturing. Productivity and stability of expression are thus the prerequisites for developing commercially viable processes…
Citation:
Kobr M, Chetellard P, Imhof MO. Expression Vector Engineering for Cell Line Development — New Roles for “Old” Sequences. BioProcess J, 2008; 7(2): 16-20. http://dx.doi.org/10.12665/J72.Imhof