By Hans J. Johansson, Hans Berg, Patrick Gilbert, Mark Hicks, Serguei Kosvintsev, and Charlotte Vassay-Jones
Volume 14, Issue 2 (Summer 2015)
Agarose-based chromatography beads were first introduced by Stellan Hjertén in 1962. Fifty years later, beaded agarose has become the dominant resin for protein purification and is extensively used, ranging from research-scale in sub mL volumes to full-scale manufacturing in > 500 L chromatography columns. Recent resin development work has focused on increasing capacity and selectivity through different grafting technologies and ligand developments…
Citation: Johansson HJ, Berg H, Gilbert P, Hicks M, Kosvintsev S, Vassay-Jones C. Achieving MAb binding greater than 120 mg/mL with novel, high-flow agarose ion exchange resins. BioProcess J, 2015; 14(2): 33–6. http://dx.doi.org/10.12665/J142.Johansson
Posted online July 10, 2015