Identification of Worst-Case Model Viruses for Low and High pH Inactivation

by Raymond Nims, S. Steve Zhou, and Mark Plavsic
Volume 16, Issue 1 (Spring 2017)

In this paper, we review the efficacy data for low and high pH inactivation of viruses in solutions (i.e., liquid inactivation) and discuss the mechanisms of action and the impact of temperature and treatment time, as these are the primary determinants of inactivation efficacy, besides pH, for different viruses. Only enveloped viruses were considered for low pH inactivation, as the literature concerning low pH inactivation of non-enveloped virus is not extensive and low pH is not considered to be an effective inactivation approach for most non-enveloped viruses. We conclude that for low pH treatment of enveloped viruses, and high pH treatment of both enveloped and non-enveloped viruses, an enteric flavivirus such as bovine viral diarrhea virus represents a worst-case model virus…

Nims R, Zhou SS, Plavsic M. Identification of worst-case model viruses for low and high pH inactivation. BioProcess J, 2017; 16(1): 7–14.

Posted online May 8, 2017.