by Katherine F. Bergmann, PhD and Leonard J. Schiff, PhD
Volume 2, Issue 1 (January/February 2003)
Various systems are used for production of biopharmaceuticals, including bacteria, yeast, mouse ascites, and animal cell culture. Each production system has its own set of risk factors for infection by viruses and their potential transmission in the final product. Viral contamination in products can arise from the animals themselves, from environmental sources, from the starting cells, or from materials introduced during the production and purification procedures. Methods have been developed for the prevention and control of these risks. The strategy used to minimize the risk of viral contamination combines several levels of viral safety…
Citation:
Bergmann KF, Schiff LJ. Assuring Viral Safety in Products Produced in Milk from Transgenic Animals: What Can Be Learned from Ascites-Derived Products. BioProcess J, 2003; 2(1): 62-65.