by Scott T. Waniger and Mark D. Hirschel, PhD
Volume 2, Issue 4 (July/August 2003)
Cell culture was first devised at the beginning of the 20th century as a method for studying the behavior of animal cells free of systemic variations that might arise in the animal both during normal homeostasis and under the stress of an experiment. During the past thirty, thousands of academic and for-profit organizations have come to rely on cultivation of animal cells as the basic foundation to perform biomedical research and large-scale biomanufacturing. Their success is directly dependent upon the reproducible production of high quality cell culture products. The complexity of the mammalian cell, its growth and storage requirements, and the need to maintain pure and uncontaminated cultures is a constant challenge to those involved with in vitro cell culture…
Citation:
Waniger ST, Hirschel MD. Mammalian Cell Culture: A Quality Approach. BioProcess J, 2003; 2(4): 61-67.