About the LVVRM:
This reference material is intended for use by organizations that are developing lentiviruses for use in gene and cellular therapies to help qualify, or validate, their internal reference material and assays. This is not to be used as a routine, internal reference material.
Data developed and compared to the LVVRM will provide tremendous value to the organization developing a product, as well as FDA CBER, which can use the LVVRM to compare product submissions.
Status:
- Available for purchase
Characterization:
- Data forthcoming
Papers, Presentations, and Posters:
- Large-Scale Production and Purification of a Lentiviral Vector Reference Material – BPJ article posted online Nov. 11, 2025
- Development of a Scalable Fed-Batch Bioreactor Process for High-Titer Production of Lentiviral Vector Using an Inducible HEK293 Producer Cell Line – BPJ article posted online Nov. 7, 2024
- Inducible Packaging Cells for Large-Scale Production of Lentiviral Vectors in Serum-Free Suspension Culture – article published in March 2008
- Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines – article published in 2017
- An Overview of the LVVRM Initiative – PowerPoint presentation on March 7, 2017
- LVVRM Upstream Development and Scale-Up Poster – poster presented in March 2023
- LVVRM Project Contributions Poster – poster presented in March 2023
- Large-Scale Production of an LVVRM — Upstream Process – PowerPoint slides dated October 30, 2023
- From 2005 — Report from the Lentivirus Vector Working Group: Issues for Developing Assays and Reference Materials for Detecting Replication-Competent Lentivirus in Production Lots of Lentivirus Vectors – BPJ article published in March/April 2005 issue
Vector Sequence:
Lentiviral Vector Working Group Participants:
- Participant List – dated August 24, 2020
Contributors:
We would like to express our sincere appreciation for the consumable products and testing services these fine organizations have donated to the Lentiviral Vector Reference Material Project (LVVRM).
