by Maik W. Jornitz and Theodore H. Meltzer
Volume 5, Issue 4 (Winter 2006)
The aim in process filtrations is to purify the liquid preparation by removing particulate impurities while obtaining as large a throughput as possible under practical conditions. The rate of flow should be expeditious enough to meet time constraints when necessary. This places a focus on the applied differential pressure level that motivates the liquid flow. A balance must be sought. Higher differential pressures increase the flow rates but may decrease throughputs by compaction of the filter cake. Also, higher applied pressures may minimize the adsorptive retention of particles. Deciding which is the proper filter involves small-scale filtration trials. The choice of the filter having been made, its size, in terms of the area necessary for the processing of the production batch, is arrived at by extrapolations from the small-scale tests that were performed…
Citation:
Jornitz MW, Meltzer TH. The Scaling of Process Filters By Flow Decay Studies. BioProcess J, 2006; 5(4): 53-56. https://doi.org/10.12665/J54.JornitzMeltzer