Smart-Flow Technology: Optimizing Tangential Flow Filtration

by Henry B. (Hank) Kopf and Marcelo Tellez
Volume 5, Issue 2 (Summer 2006)

Optimal process development creates unit operations that effectively generate, separate, and concentrate a broad array of products. Historically, tangential flow filtration (TFF) process capabilities have been limited by technological and flow restrictions. Recent innovations in TFF module design have dramatically increased the capabilities of TFF to better achieve processing objectives. NCSRT has established a best practices protocol for developing clarification, fractionation, and concentration processes for mammalian, bacteria, yeast, insect, and virus based production systems. This article presents the development platform, supplemented with application-specific expertise…

Kopf HB, Tellez M. Smart-Flow Technology: Optimizing Tangential Flow Filtration.BioProcess J, 2006; 5(2): 51-58.