by Jie Chen, Elliot Haimes, Jenifer Tetrault, Yanyu Zhang, and Arthur Ley, PhD
Volume 5, Issue 3 (Fall 2006)
The diversity of the antibody-antigen interaction and our ability to manipulate this interaction has created an enormous potential for the discovery and development of IgG therapeutics and diagnostics. Along with the expanding clinical pipeline of antibody products, increasing efforts have been devoted to improving antibody production and purification procedures. In order to meet drug discovery needs with limited resources, the so called “flexible generic purification scheme” approach has been adopted to develop a robust manufacturing process that allows the application of similar operational conditions to different monoclonal antibody molecules…
Citation:
Chen J, Haimes E, Tetrault J, Zhang Y, Ley A. Physical-Chemical Antibody Properties Determine Optimal Separation Modes for Protein A Removal. BioProcess J, 2006; 5(3): 47-53. https://doi.org/10.12665/J53.Chen