by Keith D. Miller, PhD, Johnway Gao, PhD, Brian S. Hooker, PhD
Volume 3, Issue 2 (March/April 2004)
The use of plants as protein expression hosts for human therapeutic proteins is emerging as a safe and cost-effective alternative to microbial and mammalian cell culture. Pharmaceutical protein production is typically carried out in microbes and mammalian cell culture because of their high production potential and/or ability to produce complex eukaryotic proteins. However, immense costs are typically required for production facilities to support their growth. To offset these costs, companies usually build and expand a production facility over several years. In fact, it has been predicted that the demand for high-value pharmaceuticals produced by cell culture will quickly surpass the ability of pharmaceutical companies to produce them…
Citation:
Miller KD, Gao J, Hooker BS. Initial Clarification by Aqueous Two-Phase Partitioning of Leaf Extracts from Solanum tuberosum Plants Expressing Recombinant Therapeutic Proteins. BioProcess J, 2004; 3(2): 47-51.