Scale-Down Models to Support Process Characterization

by Barney Zoro and Kevin McHugh
Volume 19, Open Access (Jan 2020)

Process characterization using qualified scale-down models (SDM) offers time and resource-saving advantages to companies developing biotherapeutics. Current approaches with glass benchtop bioreactors as SDMs have demonstrated the ability to predict process performance and product quality, but are throughput- limited by infrastructure that requires significant operational input, as well as large volumes of media and reagents. In this article, the Sartorius Stedim Biotech ambrĀ®250 high-throughput, single-use mini bioreactor system will be discussed for its suitability as an SDM for process characterization.

Citation:
Zoro B, McHugh K. Scale-down models to support process characterization. BioProcess J, 2020; 19. https://doi.org/10.12665/J19OA.Zoro

Posted online Jan 25, 2020.