Serum: What, When, and Where?

by Rosemary J. Versteegen, PhD
Volume 15, Issue 1 (Spring 2016)

For over 80 years, fetal bovine serum (FBS) and other animal-derived materials have been widely used in the production of vaccines, and more recently, biotherapeutics, for both human and animal applications. Ever since FBS was initially developed as a cell culture reagent, there have been efforts made to avoid the use of this critical commodity. The International Serum Industry Association (ISIA) recognizes the requirement for robust risk assessment and management, and has several ongoing programs designed to help mitigate the risk of using animal-derived materials. This article will provide an outline of the state of the industry and of these programs...

Versteegen RJ. Serum: what, when, and where? BioProcess J, 2016; 15(1): 18–21.

Posted online April 7, 2016.