Deploying Automated Buffer Production for cGMP Use: Points to Consider

by Amos M. Tsai, Enrique Carredano, and Karolina Busson
Volume 18, Open Access (January 2019)

Biopharmaceutical manufacturing often takes place in tank farms – facilities in which large-volume vessels are used to support cell culture processes with equally sized, or even larger buffer preparation and storage tanks to support downstream processing. While the large cell culture vessels used to produce products are justifiable, current downstream buffer management approaches relying on high-capacity tanks lead to constraints on facility construction, operations, and plant flexibility....

Tsai AM, Carredano E, Busson K. Deploying automated buffer production for cGMP use: Points to consider. BioProcess J, 2019; 18.

Posted online January 8, 2019.