Model and Method for Optimal Sizing of Serial Microfiltration Systems

by Sal Giglia and Greg Straeffer
Volume 12, Issue 3 (Fall 2013)

Classical filtration fouling models do not accurately predict fouling behaviors for sterilizing filtration applied to some bioprocess fluids, particularly when filters are operated in series. To overcome the limitations of these models, we extended a previously developed single-stage fouling model that combined blocking and adsorption mechanisms to dual filters operated in series. Our model demonstrates improvements in predicting bioprocess fluid filtration performance accuracy when applied to microfiltration membranes operated in series, from measured performance of each membrane filter operated individually. In addition, the model and developed method allows for rapid and efficient optimization of prefiltration to final filter area ratios. In redundant sterile filtration, two filters with the same pore size rating are operated in series to protect against an integrity failure of the primary sterilizing filter. Prefilters can also be used to protect final sterilizing-grade membrane filters from excessive fouling which in turn offer the benefits of reduced costs and filtration time...

Giglia S, Straeffer G. Model and Method for Optimal Sizing of Serial Microfiltration Systems. BioProcess J, 2013; 12(3): 31-39.

Posted online September 30, 2013.