Circovirus Inactivation: A Literature Review

by Raymond Nims, PhD and Mark Plavsic, PhD, DVM
Volume 11, Issue 1 (Spring 2012)

A fairly extensive body of literature exists on the inactivation of the circovirus by physical (e.g., heat, irradiation) and chemical means(e.g., disinfection). This is probably due to the fact that the circovirus is an economically significant pathogen within the swine and poultry industries. Sufficiently high temperatures afford substantial circovirus inactivation as do certain disinfectants and chemicals. However, there have been relatively few reports on the use of irradiation as an inactivation approach for this family of viruses. There is empirical evidence that gamma irradiation, at the doses normally employed for risk mitigation (25–45 kGy), is relatively ineffective on circoviruses. Fortunately, data on the effectiveness of ultraviolet radiation in the C range (UV-C, 248–254 nm, max) for the inactivation of other single-stranded DNA viruses (e.g., parvovirus) have been used in two orthogonal prediction models which estimate that the circovirus should be similarly sensitive to UV-C irradiation. Overall, appropriately-selected inactivation approaches may provide a high degree of risk mitigation for the circoviruses, whether present as contaminants of facility surfaces, animal-derived raw materials, or other process additives...

Nims R, Plavsic M. Circovirus Inactivation: A Literature Review. BioProcess J, 2012; 11(1): 4-10.

Posted online March 12, 2012.