Engineering MVM Resistance in CHO Cells

by Joaquina Mascarenhas, Trissa Borgschulte, and Henry George
Volume 16, Issue 1 (Spring 2017)

For decades, Chinese hamster ovary (CHO) cells have proven to be indispensable for the biopharmaceutical manufacturing industry, serving as cell factories that reliably produce grams per liter of recombinant proteins with the appropriate post-translational modifications and protein folding. However, one of the challenges of working with mammalian cells is that they are susceptible to viral contamination. Although the adoption of a wide range of risk mitigation strategies has made viral contamination a rare event, staggering costs and a shortage of life-saving medicines can result when these prevention strategies do fail, as demonstrated by a number of high-profile contamination events within the industry…

Mascarenhas J, Borgschulte T, George H. Engineering MVM resistance in CHO cells. BioProcess J, 2017; 16(1): 65–8.

Posted online May 8, 2017.