Bioprocessing Aspects of Neural Stem Cell Production in Bioreactors

by Leo A. Behie, PhD, Michael S. Kallos, PhD, and Arindom Sen, PhD
Volume 3, Issue 4 (July/August 2004)

Neurodegenerative diseases such as Parkinson’s disease and multiple sclerosis, along with injuries such as stroke affect millions of individuals worldwide and costs healthcare systems billions of dollars each year in North America alone. The diseases result from the death of specific cell types within the central nervous system. Current treatment efforts have focused primarily on alleviating symptoms using pharmaceuticals. However, recent advances in our understanding of these conditions, coupled with advances in biology, genomics, transplantation, and biochemical engineering are making cell therapy (the transplantation of viable cells to replace dead cells) more attractive as a potential avenue of treatment…

Behie LA, Kallos MS, Sen A. Bioprocessing Aspects of Neural Stem Cell Production in Bioreactors. BioProcess J, 2004; 3(4): 27-42.